Pharmacogenetics and epigenetics in toxicology
A.A. 2018/2019
Learning objectives
This course will provide the basic knowledge to understand the molecular basis of the genetic differences in metabolic pathways which may affect individual responses to CBP; furthermore, it will set the theoretical basis for understanding how these individual responses might be influenced by the epigenoma and can be epigenetically inherited. The concepts of germline (single nucleotide polymorphisms) and epigenetic mutations will be developed to understand how genomic and epigenomic mutations contribute to the differential susceptibility to xenobiotics. The impact of the sequencing of the human genome will be discussed in light of the most updated genomic technologies applied to pharmacotoxicology and ecotoxicology fields.
Expected learning outcomes
Non definiti
Periodo: Secondo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Course syllabus and organization
Edizione unica
Responsabile
Periodo
Secondo semestre
Programma
The course will focus on pharmacogenetics, a subset of genetics, addressing both the past findings and the future directions. The idea behind pharmacogenetics is that a person's genes influence their responses to medicinal drugs; therefore, the course will address the concept of "personalized medicine". The course will provide students with a solid knowledge on epigenetic modifications and on the techniques and methods that have been developed to analyse them. In addition, the role of epigenetic modifications in diseases pathogenesis will be addressed. The contribution of genomic and epigenomic mutations to the differential susceptibility to xenobiotics will be tackled.
Prerequisiti
A basic knowledge in cell and molecular biology is recommended. The final exam is oral and covers all the topics presented during lectures. It consists of a couple of open questions and the presentation of a scientific article covering one of the topics of the course.
Professor(s)