Quantitative Analysis According to Pharmacopoeia and Laboratory of Quantitative Analysis
A.Y. 2025/2026
Learning objectives
The course is organized in two different and complementary didactic units: lectures (Quantitative Analysis according to Pharmacopoeia) and individual laboratory training (Laboratory of Quantitative analysis according to Pharmacopoeia). The lectures mainly aim at providing the students the necessary competences for properly applying the analytical methods, partially covered by preparatory courses (General Inorganic Chemistry and Stoichiometry, Analytical Chemistry and Inorganic qualitative analysis according to Pharmacopoeia and the Laboratory of Inorganic Quantitative Analysis), which are described in the actual version of the European Pharmacopoeia, for the quantitative analysis of pharmaceutical substances. Concerning the individual laboratory training, the main object is to provide the proper skills for dosing the pharmaceutical substances reported in both the Italian Official Pharmacopoeia and in the European Pharmacopoeia.
Expected learning outcomes
The lectures will help the student to reach a complete control regarding the theory of quantitative analysis, the application of the various analytical methods, proposed by Pharmacopoeia, and above all the critical evaluation of the analytical data.
The individual laboratory training will give the student a sufficient operative autonomy, for the application of the main quantitative methods reported in the European Pharmacopoeia, applied to pharmaceutical substances.
The individual laboratory training will give the student a sufficient operative autonomy, for the application of the main quantitative methods reported in the European Pharmacopoeia, applied to pharmaceutical substances.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Linea AL
Responsible
Lesson period
Second semester
Course syllabus
Programme of the lectures:
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European Pharmacopoeia as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: Definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - nonaqueous titrations.
Analytical techniques described in the current European Pharmacopoeia applied to quantitative analysis.
Introduction to analytical techniques; ; optical methods: UV-Visible spectroscopy, hints of fluorescence and phosphorescence; chromatography techniques: high-performance liquid chromatography, gas-chromatography and Headspace analysis.
Programme of the laboratory exercises:
- Description of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- Complexation titrations
- Oxidation-reduction titration (permanganometry, iodimetry, Iodometry)
- Acid- base titrations
- Precipitation titrations.
- Uv-visible spectroscopy application
- High performance liquid chromatography application.
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European Pharmacopoeia as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: Definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - nonaqueous titrations.
Analytical techniques described in the current European Pharmacopoeia applied to quantitative analysis.
Introduction to analytical techniques; ; optical methods: UV-Visible spectroscopy, hints of fluorescence and phosphorescence; chromatography techniques: high-performance liquid chromatography, gas-chromatography and Headspace analysis.
Programme of the laboratory exercises:
- Description of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- Complexation titrations
- Oxidation-reduction titration (permanganometry, iodimetry, Iodometry)
- Acid- base titrations
- Precipitation titrations.
- Uv-visible spectroscopy application
- High performance liquid chromatography application.
Prerequisites for admission
The course takes place in the second semester of the second year. The students are expected to have Analytical Chemistry, Inorganic qualitative analysis according to Pharmacopoeia and the Laboratory of Inorganic Quantitative Analysis and Organic Chemistry knowledges.
Teaching methods
The course is structured in lectures and laboratory exercises (mandatory), The laboratory exercises are fully explained during lectures beside being supported by instructional videos of the related programme.
All information about the program and educational materials (slide) are available on the course website on myAriel platform.
All information about the program and educational materials (slide) are available on the course website on myAriel platform.
Teaching Resources
Recommended books:
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM webs
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM webs
Assessment methods and Criteria
The examination consists of a written test (120 minutes duration) based on problems related to the stechiometry and the chemical equilibrium of the various titration reactions, by critical evaluation of the analytical data, and questions concerning the theory of quantitative analysis and the application of the various analytical methods. The overall assessment is scored in thirtieth and it corresponds to the sum of the scores obtained in the written test (maximum score 24/30) and in the laboratory exercises (maximun score 6/30). The final score of the examination is communicated during the return and correction of the test. In the course of the lectures, ongoing exercises are proposed in preparation for the examination.
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 8
Single bench laboratory practical: 32 hours
Lessons: 48 hours
Lessons: 48 hours
Professors:
Gelain Arianna, Straniero Valentina
Shifts:
Professor:
Gelain Arianna
Turno 1
Professor:
Straniero ValentinaLinea MZ
Responsible
Lesson period
Second semester
Course syllabus
Programme of the lectures:
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European Pharmacopea as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: Definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - nonaqueous titrations.
Analytical techniques described in the current European Pharmacopea applied to quantitative analysis.
Introduction to analytical techniques; optical methods: UV-Visible spectroscopy, hints of fluorescence and phosphorescence; chromatography techniques: high-performance liquid chromatography, gas-chromatography and Headspace analysis.
Programme of the laboratory exercises:
- Description of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- Complexation titrations
- Oxidation-reduction titration (permanganometry, iodimetry, Iodometry)
- Acid- base titrations
- Precipitation titrations.
- Uv-visible spectroscopy application
- High performance liquid chromatography application.
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European Pharmacopea as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: Definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - nonaqueous titrations.
Analytical techniques described in the current European Pharmacopea applied to quantitative analysis.
Introduction to analytical techniques; optical methods: UV-Visible spectroscopy, hints of fluorescence and phosphorescence; chromatography techniques: high-performance liquid chromatography, gas-chromatography and Headspace analysis.
Programme of the laboratory exercises:
- Description of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- Complexation titrations
- Oxidation-reduction titration (permanganometry, iodimetry, Iodometry)
- Acid- base titrations
- Precipitation titrations.
- Uv-visible spectroscopy application
- High performance liquid chromatography application.
Prerequisites for admission
The course takes place in the second semester of the second year. The students are expected to have Analytical Chemistry, Inorganic qualitative analysis according to Pharmacopoeia and the Laboratory of Inorganic Quantitative Analysis and Organic Chemistry knowledges.
Teaching methods
The course is structured in lectures and laboratory exercises (mandatory), The laboratory exercises are fully explained during lectures beside being supported by instructional videos.
All information about the program and educational materials (slide) are available on the course website on myAriel platform.
All information about the program and educational materials (slide) are available on the course website on myAriel platform.
Teaching Resources
Recommended books:
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM webs
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM webs
Assessment methods and Criteria
The examination consists of a written test (90 minutes duration) based on problems related to the stoichiometry and the chemical equilibrium of the various titration reactions, by critical evaluation of the analytical data, and questions concerning the theory of quantitative analysis and the application of the various analytical methods. The overall assessment is scored in thirtieth and it corresponds to the sum of the scores obtained in the written test (maximum score 24/30) and in the laboratory exercises (maximun score 6/30). The final score of the examination is communicated during the return and correction of the test. In the course of the lectures, ongoing exercises are proposed in preparation for the examination.
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 8
Single bench laboratory practical: 32 hours
Lessons: 48 hours
Lessons: 48 hours
Professor:
Fumagalli Laura
Shifts:
Professor:
Fumagalli Laura
Turno 2
Professor:
Fumagalli LauraProfessor(s)