Formulation and Legislation of Health Products
A.Y. 2018/2019
Learning objectives
This course allows the student to acquire basic knowledge of formulation, preparation and storage of healthy products, in particular solid and liquid dosage forms for oral intake. The basic training goal is to provide the student with the tools to identify problems related to the administration of plant-based preparations in a form and mode that ensure their acceptability and activity.
Training objectives in detail: the key role played by the dosage form in determining the availability of the active ingredient in the site of action is illustrated, a role that is related to the physical-technological and biopharmaceutical properties of the healthy product, also depending on the mode and route of administration. The criteria for classifying dosage forms (conventional and modified release formulations) and formulation strategies for the production of mainly oral solid (powders, granules, tablets, capsules) and liquid (solutions) forms are provided. The main operations and equipment involved in the preparation, on a laboratory and industrial scale, and in the control of the finished product are described.
Teaching also includes 16 hours of compulsory individual practicals.
Training objectives in detail: the key role played by the dosage form in determining the availability of the active ingredient in the site of action is illustrated, a role that is related to the physical-technological and biopharmaceutical properties of the healthy product, also depending on the mode and route of administration. The criteria for classifying dosage forms (conventional and modified release formulations) and formulation strategies for the production of mainly oral solid (powders, granules, tablets, capsules) and liquid (solutions) forms are provided. The main operations and equipment involved in the preparation, on a laboratory and industrial scale, and in the control of the finished product are described.
Teaching also includes 16 hours of compulsory individual practicals.
Expected learning outcomes
Undefined
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Lesson period
First semester
Course syllabus
- Introduction
- Dosage forms. Definition and classification. Administration routes
- Biopharmaceutics: LADME processes, descriptive pharmacokinetic parameters, absolute and relative bioavailability
- Powders: properties and characterization
- Unitary operations (grinding, mixing and drying): rationale, mechanisms, equipment
- Granulation: rationale, mechanisms, equipment
- Compression: compression physics, equipment setting
- Formulation and preparation of solid dosage forms: tablets, capsules, lozenges, chewing gums. Technological and biopharmaceutical tests
- Coating of solid dosage forms
- Modified-release dosage forms for oral administration
- Formulation and production factors that affect bioavailability. Solid State. Noyes -Whitney's Equation
- Formulation and preparation of liquid oral dosage forms
- Notes on packaging and stability of dosage forms
- Dosage forms. Definition and classification. Administration routes
- Biopharmaceutics: LADME processes, descriptive pharmacokinetic parameters, absolute and relative bioavailability
- Powders: properties and characterization
- Unitary operations (grinding, mixing and drying): rationale, mechanisms, equipment
- Granulation: rationale, mechanisms, equipment
- Compression: compression physics, equipment setting
- Formulation and preparation of solid dosage forms: tablets, capsules, lozenges, chewing gums. Technological and biopharmaceutical tests
- Coating of solid dosage forms
- Modified-release dosage forms for oral administration
- Formulation and production factors that affect bioavailability. Solid State. Noyes -Whitney's Equation
- Formulation and preparation of liquid oral dosage forms
- Notes on packaging and stability of dosage forms
CHIM/09 - PHARMACEUTICAL AND TECHNOLOGICAL APPLICATIONS OF CHEMISTRY - University credits: 6
Single bench laboratory practical: 16 hours
Lessons: 40 hours
Lessons: 40 hours
Professor:
Ochoa Evelyn
Shifts:
Professor:
Ochoa Evelyn
Turno 1
Professor:
Ochoa EvelynTurno 2
Professor:
Ochoa Evelyn