Differentiation Biology and Cell Therapies

-Cell differentiation: definition, molecular mechanisms, survival, normal and pathological differentiation, (metaplasia, anaplasia).
-Cell Therapy: Backgroun. Current approaches and Prospects of cell therapy.
- Stem cells, progenitors and differentiated cells. Tissue turnover. The origin of embryonic stem cells and during post-embryonic development. iPS.
-Tissue regeneration.

-Epithelia. The epithelial stem cells. Cell and gene therapy for genetic and acquired diseases of epithelia.
-Cartilage and bone. The stem cells of the bone. Cell therapy for cartilage and bone.
-The skeletal muscle tissue. Satellite cells and other progenitors. Stem cell therapy for genetic diseases of skeletal muscle.
-The cardiac muscle tissue. Stem cells and progenitors. Stem cell therapy for myocardial infarction and chronic cardiomyopathy.
-The blood and lymph vessels. The endothelial progenitors. Angiogenesis and anti-angiogenesis.
-The bone marrow and blood. Cell and gene therapy of congenital and acquired diseases of the blood.
-The central nervous system and peripheral. Cell and gene therapy. Parkinson' disease, Multiple Sclerosis, SLA, Huntington's disease.
-A cell for all tissues: Embryonic stem cells and iPS. Cloning. Therapeutic perspectives and remaining problems.
- Pancreas and Diabetes: cell therapies
- Cell-transplantation. The administration routes, l '"homing", the survival, morphological and functional integration into the host tissue, the functional recovery, the inflammatory and immune response to transplantation.
-From pre-clinical to clinical trials and clinical routine.


Tutorials
Reference Material
Gilbert- Developmental Biology- ed. Zanichelli
Slides loaded on Professor web-site on Ariel


Prerequisites and examination procedures
Cytology and Histology
Developmental Biology
Molecular Biology and Genetics
Oral examination


Teaching Methods
Lectures


Language of instruction
Italian


Program information
Professor web-site on Ariel